Snake venom: a potent
anticancer agent.
Source
IGNOU-I2IT Centre of Excellence for Advanced
Education and Research, Pune, Maharashtra, India.
Abstract
Since cancer is one of the leading causes of
death worldwide, and there is an urgent need to find better treatment. In
recent years remarkable progress has been made towards the understanding of
proposed hallmarks of cancer development and treatment. Treatment modalities
comprise radiation therapy, surgery, chemotherapy, immunotherapy and hormonal
therapy. Currently, the use of chemotherapeutics remains the predominant option
for clinical control. However, one of the major problems with successful cancer
therapy using chemotherapeutics is that patients often do not respond or
eventually develop resistance after initial treatment. This has led to the
increased use of anticancer drugs developed from natural resources. The biodiversity of venoms and toxins makes
them a unique source from which novel therapeutics may be developed. In
this review, the anticancer potential of snake venom is discussed. Some of the
included molecules are under clinical trial and may find application for
anticancer drug development in the near future.
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