Mushroom Extracts
Several species of higher fungi
have been used traditionally as well as in modern times in the treatment of
cancer. The most commonly used medicinal mushrooms are Trametes versicolor
(Turkey Tail, formerly Coriolus versicolor), Ganoderma lucidum (Reishi),
Lentinus edodes, Grifola frondosa (Maitake), and Schizophyllum commune. Because
of their broad immune activity, medicinal mushrooms are usually prescribed
because of their immunomodulation activity. While other natural products from
other plant species have known immunomodulatory activities, polysaccharides
extracted from certain mushroom species have been the most thoroughly studied
in pre-clinical and clinical studies.
Ganoderma (REISHI), Shiitake,
Maiitake
These are mushrooms that have shown
promising results as adjunctive therapy in pre-clinical research. However, lack
of clear clinical data precludes us from recommending these extracts.
Trametes Versicolor
Trametes versicolor (T. versicolor), also known as
Coriolus versicolor or Polyporus versicolor, has a long history of medical use
in Asia dating back hundreds of years in traditional Asian medicine. It is the
most widely studied of all medicinal mushrooms and there is a wealth of data
published in Asia about its immune-modulatory effects, including clinical
trials.
Efficacy
Trametes versicolor, has been
assessed in phase I, II, and III randomized clinical trials in stomach,
colorectal, esophageal, and breast cancer patients. Several clinical studies
report significant immunologic and/or oncologic benefit of these fractions as
adjunctive therapy in lung cancer patients gastrointestinal cancers, and breast
cancer.
Clinical trials using active
fractions of Trametes (namely PSK and PSP) published in Japan and Korea suggest
that T. versicolor polysaccharide-peptide constituents improve disease-free and
overall survival in several different types of cancer, including stomach,
esophagus, lung, colorectal, prostate, and breast adenocarcinomas. In Japan,
PSK is a therapy prescribed to cancer patients routinely, both during and after
radiation and chemotherapy, and it is a cancer therapy approved by the Japanese
National Health Registry. However, no clinical trials have yet been carried out
in the US.
Safety
Toxicological assessments
indicate that PSK and PSP have low toxicity with no reports of abnormalities in
animals or humans following acute and chronic toxicity tests.
Recommendations
The strong clinical data for PSK
/ Trametes versicolor warrants its inclusion in secondary prevention planning and
is routinely prescribed for cancer patients after completion of primary cancer
treatment to restore and improve immune function. Many of the controlled trials
conducted in Japan used PSK concurrently with chemotherapy showing improved
outcomes relative to those cancer patients who received standard treatment
alone. Several U.S companies make PSK-like medicinal mushroom products. Many
integrative oncologists prescribe 3000-4500 mg of PSK™ or similar products
after chemotherapy and radiation to restore immune status.
http://depts.washington.edu/integonc/clinicians/act/mushroom_extracts.shtml
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