Quercetin
Quercetin is a bioflavonoid found
in high concentrations in onions, red wine, green tea and herbal extracts such
as St. John's wort. Quercetin is frequently used in natural medicine because of
antioxidant properties.
Efficacy
Preclinical data from in-vitro
studies have shown anti-neoplastic activity in various types of cell lines.
Quercetin has also shown to inhibit P53 gene mutations.
While there are few clinical
studies assessing the anticancer actions of quercetin, evidence suggest
antineoplastic effects of quercetin. For example, one such pilot trial assessed
the effect of 60 mg of quercetin along with 1440mg curcumin daily in 5 patients
with familial adenomatous polyposis (FAP). All 5 patients had a decrease in
polyp number and size from baseline of 60.4% (P<0.05) and 50.9%(P<0.05)
respectively after a mean of 6 months of treatment. There were no adverse
effects reported.
Safety
Doses up to 1000 mg/day for up to
12 weeks have been shown well tolerated for human consumption.
Recommendations
Quercetin is used in naturopathic
medical practice in doses of 500-3000 mg/day as post-chemotherapy adjuvant
therapy to stabilize the P53 gene. Since it inhibits the release of histamine
it is also prescribed for cancer patients with Ig E-mediated allergies. Courses
of quercetin treatment may range from weeks to months. Some cancer patients,
especially those with IgE-mediated allergies remain on low dose quercetin (500
mg/day) for years to manage allergies and prevent cancer recurrence.
http://depts.washington.edu/integonc/clinicians/act/quercetin.shtml
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