[Treatment of actinic keratoses
with birch bark extract: a pilot study]
[Article
in German]
Universitats-Hautklinik,
Hauptstr. 7, D-79104 Freiburg .
BACKGROUND:
Birch bark contains a variety of apoptosis-inducing
and anti-inflammatory substances such as betulinic acid, betulin, oleanolic
acid and lupeol. Therefore, birch bark extract may be effective in the
treatment of actinic keratoses. To address this issue, a pilot study using a
standardized birch bark ointment was performed. METHODS: Twenty-eight patients
with actinic keratoses were enrolled in this prospective, non-randomized pilot
study. Fourteen patients were treated with birch bark ointment only; fourteen
patients received a combination therapy with cryotherapy and birch bark
ointment. Treatment response was assessed clinically after two months. RESULTS:
Clearing of more than 75 % of the lesions was seen in 79 % of the patients
treated with birch bark ointment monotherapy. The response rate of the combined
treatment modality was 93 %. Therapy with birch bark ointment was well
tolerated. CONCLUSION: In this pilot study, a standardized birch bark extract
was effective in the treatment of actinic keratoses. This therapy is easy to
perform and it has no side effects. Birch bark ointment may be a new
therapeutic option for actinic keratoses.
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