Laman ini diujudkan buat anda yang mencari kaedah ubatan herba alam semulajadi untuk sakit barah, selain berkongsi pendapat dan pengalaman sesama ahli. Menyedari faktor penyebab barah selain mengelak penipuan kerana pesakit barah selalu ditipu oleh orang yang rakus mengaut untung semata-mata. Laman ini juga bertujuan menyingkap amalan buruk yang merugikan kita.
Faculty of Pharmacy, Division of
Pharmaceutical Chemistry, University of Helsinki , Helsinki , Finland .
Betulin (lup-20(29)-ene-3beta,28-diol) is an
abundant naturally occurring triterpene and it is found predominantly in bushes
and trees forming the principal extractive (up to 30% of dry weight) of the bark of birch trees .
Presently, there is no significant use for this easily isolable compound, which
makes it a potentially important raw material for polymers and a precursor of
biologically active compounds. Betulin
can be easily converted to betulinic acid, which possesses a wide spectrum of
biological and pharmacological activities. Betulinic acid has antimalarial and
anti-inflammatory activities. Betulinic acid and its derivatives have
especially shown anti-HIV activity and cytotoxicity against a variety
of tumor cell lines comparable to some clinically used drugs .
A new mechanism of action has been confirmed for some of the most promising
anti-HIV derivatives, which makes them potentially useful additives to the
current anti-HIV therapy. Betulinic
acid is specifically cytotoxic to several tumor cell lines by inducing
apoptosis in cells. Moreover, it is non-toxic up to 500 mg/kg body weight in
mice. The literature concerning derivatization of betulin for
structure-activity relationship (SAR) studies and its pharmacological
properties is reviewed.